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Saturday, May 4, 2013

Non small cell lung cancer stage 3 | life expectancy

Stage III non small cell lung disease — life expectancy

stage-3-non-small-cell -lung cancerConsider the life and survival.. Methods for the treatment and diagnosis of the disease.. Read carefully! It's not as bad as it seems..
 
Stage III non-small cell lung cancer or locally advanced tumor, brings together a series of steps by the system TNM. The first is to discuss the treatment of tumors of stage IIIB, because it has a more uniform approach. The probability of cure is quite a wide range. Tumor under IIIB considered inoperable because in this case the loss of vital tissues, spread to the lymph nodes of the contralateral side of the chest, as well as neoplastic pleural effusion and its colonization atypical cells.
Downstream stage IIIB with tumor exudate is close to stage IV non-small cell lung cancer, and in such cases, the treatment is palliative and includes, as a rule, only chemotherapy. For the treatment of patients with stage IIIB non-small cell lung cancer apply radical chemotherapy and radiation therapy, except when in the pleural cavity is detected tumor effusion.
When using the cisplatin-based chemotherapy with radiotherapy survival better than the sequential application of these methods, or when only radiotherapy. Therefore, for the treatment of patients with unresectable stage III non-small cell lung cancer and a good general state of recommended combined radiotherapy and cisplatin-based chemotherapy. The best survival rates of patients with stage IIIB non-small cell lung cancer were observed in the trial SWGG 9504, phase II of the trial, to evaluate the effectiveness of combined chemotherapy and radiation therapy followed by consolidation chemotherapy. The length of survival of patients with this treatment was 27 months., A significant increase compared to the earlier schemes applied curative treatment (15-17 months). Currently, phase III clinical trial of this.

Non small cell lung cancer stage 3aThe optimal approach for the management of lung cancer stage IDA remains a subject of controversy. Tumor stage IIIA are not the same in terms of operability, and types of surgical procedures are very different depending on the area of ​​specialization and the hospital. In the vast majority of cases the tumor refers to a stage IIIA because of metastases in the lymph nodes of level N 2 (ipsilateral mediastinal lymph nodes or the lower tracheo-bronchial lymph nodes). If the lymph nodes of level N 2 is confirmed by CT or PET, the effectiveness of surgical treatment is half that in the event that lymph nodes detected by chance at this level, biopsy or thoracotomy (overall 5-year survival rate is 13 and 23%, respectively).

These differences led to the emergence of two approaches to the treatment of patients with clinically confirmed metastases in the lymph nodes of level N2. The first approach is the only radical chemo-and radiotherapy, by analogy with the treatment of inoperable tumors of stage P1V. In the second approach is the use of preoperative (neoadjuvant) chemotherapy and radiation therapy to reduce the tumor mass and the elimination of micrometastases in the mediastinum to the operation to bring the state of the tumor to those cases where the metastases in the lymph nodes N2 level detected by accident.

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